iloperidone improves levels of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Iloperidone can be a time-dependent CYP3A inhibitor and may lead to increased plasma amounts of medicine predominantly eliminated by CYP3A4.Xiao et al (2004) employed submit mortem assessment in the brains of MPTP handled mice.
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